Study of biomineralization processes by cryo-TEM

F. Valentini, E. Landi, M. Sandri, Nico Sommerdijk, Fabio Nudelman, A. Tampieri

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


The present work describes the study of the biomineralization process of biohybrid composite for bone substitution and repair. The material was developed nucleating apatitic phases on self assembling collagen fibers , acting as a template. Using cryogenic transmission microscopy (cryo-TEM) it is possible to freeze material specimens at different times of the mineralization process and then observe the vitrified samples at cryogenic temperature. The preparation procedure of the specimens was set up. The nucleation of the apatitic phase on the collagen was observed from the beginning of the synthesis and the time needed for the complete assembling of the collagen fiber was determined.

Original languageEnglish (US)
Title of host publication2009 9th IEEE Conference on Nanotechnology, IEEE NANO 2009
Number of pages3
StatePublished - Dec 1 2009
Event2009 9th IEEE Conference on Nanotechnology, IEEE NANO 2009 - Genoa, Italy
Duration: Jul 26 2009Jul 30 2009


Other2009 9th IEEE Conference on Nanotechnology, IEEE NANO 2009


  • Apatite-collagen
  • Bio-hybrid material
  • Biomineralization
  • Component
  • Cryo-TEM

ASJC Scopus subject areas

  • Process Chemistry and Technology
  • Electrical and Electronic Engineering


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