Studies on the Metabolism of Steroids in the Foetus: Biosynthesis of 3‐Hydroxy‐Δ4‐C19 Steroids in the Human Foetal Liver

Belisário P. Lisboa; Jan‐Åke Gustafsson

doi:10.1111/j.1432-1033.1970.tb00323.x

Studies on the Metabolism of Steroids in the Foetus: Biosynthesis of 3‐Hydroxy‐Δ⁴‐C₁₉ Steroids in the Human Foetal Liver

Belisário P. Lisboa, Jan‐Åke Gustafsson

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26 Scopus citations

Abstract

After incubation of testosterone with the 105000 ×g microsome fraction from human foetal liver 4‐androstene‐3α,17β‐diol was isolated. Incubation of testosterone with the 105000 ×g supernatant fraction resulted in the formation of 4‐androstene‐3α(and 3β),17β‐diol. When incubated with liver slices testosterone was metabolized into 4‐androstene‐3α,17β‐diol and 3α‐ and 3β‐hydroxy‐4‐androsten‐17‐one.

Original language	English (US)
Pages (from-to)	556-559
Number of pages	4
Journal	European Journal of Biochemistry
Volume	14
Issue number	3
DOIs	https://doi.org/10.1111/j.1432-1033.1970.tb00323.x
State	Published - Jul 1970

ASJC Scopus subject areas

Biochemistry

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10.1111/j.1432-1033.1970.tb00323.x

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title = "Studies on the Metabolism of Steroids in the Foetus: Biosynthesis of 3‐Hydroxy‐Δ4‐C19 Steroids in the Human Foetal Liver",

abstract = "After incubation of testosterone with the 105000 ×g microsome fraction from human foetal liver 4‐androstene‐3α,17β‐diol was isolated. Incubation of testosterone with the 105000 ×g supernatant fraction resulted in the formation of 4‐androstene‐3α(and 3β),17β‐diol. When incubated with liver slices testosterone was metabolized into 4‐androstene‐3α,17β‐diol and 3α‐ and 3β‐hydroxy‐4‐androsten‐17‐one.",

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year = "1970",

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AU - Lisboa, Belisário P.

AU - Gustafsson, Jan‐Åke

PY - 1970/7

Y1 - 1970/7

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AB - After incubation of testosterone with the 105000 ×g microsome fraction from human foetal liver 4‐androstene‐3α,17β‐diol was isolated. Incubation of testosterone with the 105000 ×g supernatant fraction resulted in the formation of 4‐androstene‐3α(and 3β),17β‐diol. When incubated with liver slices testosterone was metabolized into 4‐androstene‐3α,17β‐diol and 3α‐ and 3β‐hydroxy‐4‐androsten‐17‐one.

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Studies on the Metabolism of Steroids in the Foetus: Biosynthesis of 3‐Hydroxy‐Δ⁴‐C₁₉ Steroids in the Human Foetal Liver

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