Studies on the Metabolism of C21 Steroids in Rat Liver: Hydroxylation of Progesterone in Rat Liver Microsomes

Jan‐Åke Gustafsson; Belisário P. Lisboa

doi:10.1111/j.1432-1033.1970.tb01036.x

Studies on the Metabolism of C₂₁ Steroids in Rat Liver: Hydroxylation of Progesterone in Rat Liver Microsomes

Jan‐Åke Gustafsson, Belisário P. Lisboa

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29 Scopus citations

Abstract

Progesterone was incubated with 105000 ×g liver microsome preparations from adult male rats and the hydroxylated 3‐oxo‐δ⁴‐steroids formed were isolated and identified by thin‐layer chromatography and gas chromatography‐mass spectrometry. The following compounds were characterized: 2α‐, 6β‐, 6α‐, 7α‐, 15α‐, 15β‐ and 16α‐hydroxyprogesterone.

Original language	English (US)
Pages (from-to)	525-530
Number of pages	6
Journal	European Journal of Biochemistry
Volume	15
Issue number	3
DOIs	https://doi.org/10.1111/j.1432-1033.1970.tb01036.x
State	Published - Sep 1970

ASJC Scopus subject areas

Biochemistry

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10.1111/j.1432-1033.1970.tb01036.x

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title = "Studies on the Metabolism of C21 Steroids in Rat Liver: Hydroxylation of Progesterone in Rat Liver Microsomes",

abstract = "Progesterone was incubated with 105000 ×g liver microsome preparations from adult male rats and the hydroxylated 3‐oxo‐δ4‐steroids formed were isolated and identified by thin‐layer chromatography and gas chromatography‐mass spectrometry. The following compounds were characterized: 2α‐, 6β‐, 6α‐, 7α‐, 15α‐, 15β‐ and 16α‐hydroxyprogesterone.",

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N2 - Progesterone was incubated with 105000 ×g liver microsome preparations from adult male rats and the hydroxylated 3‐oxo‐δ4‐steroids formed were isolated and identified by thin‐layer chromatography and gas chromatography‐mass spectrometry. The following compounds were characterized: 2α‐, 6β‐, 6α‐, 7α‐, 15α‐, 15β‐ and 16α‐hydroxyprogesterone.

AB - Progesterone was incubated with 105000 ×g liver microsome preparations from adult male rats and the hydroxylated 3‐oxo‐δ4‐steroids formed were isolated and identified by thin‐layer chromatography and gas chromatography‐mass spectrometry. The following compounds were characterized: 2α‐, 6β‐, 6α‐, 7α‐, 15α‐, 15β‐ and 16α‐hydroxyprogesterone.

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ER -

Studies on the Metabolism of C₂₁ Steroids in Rat Liver: Hydroxylation of Progesterone in Rat Liver Microsomes

Abstract

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