Studies on the Metabolism of C19 Steroids in Rat Liver Biosynthesis of Saturated 17‐Oxo‐C19O3 Steroids in Rat Liver Microsomes

Jan-Ake Gustafsson, Belisário P. Lisboa

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


After incubation of 4‐androstene‐3,17‐dione, 5α‐androstane‐3,17‐dione, 3α‐hydroxy‐5α‐androstan‐17‐one and 3β‐hydroxy‐5α‐androstan‐17‐one with rat liver microsomes the following steroids were isolated and identified by thin‐layer chromatography and by gas chromatography‐mass spectrometry: 3α‐ and 3β, 16α‐dihydroxy‐5α‐androstan‐17‐one, 3α‐ and 3β, 7α‐dihydroxy‐5α‐androstan‐17‐one, 3β, 7β‐dihydroxy‐5α‐androstan‐17‐one and 3β, 17β‐dihydroxy‐5α‐androstan‐16‐one. The importance of the 17‐oxo and 17β‐hydroxy pathways in the metabolism of C19 steroids in rat liver is discussed.

Original languageEnglish (US)
Pages (from-to)475-480
Number of pages6
JournalEuropean Journal of Biochemistry
Issue number3
StatePublished - Jan 1 1970

ASJC Scopus subject areas

  • Biochemistry


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