Studies on the metabolism of C19 steroids in rat liver. 7. 18-hydroxylation of 17-oxo-C19 steroids in rat liver microsomes

J. Å Gustafsson, B. P. Lisboa

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


After incubation of 4-androstene-3, 17-dione, 5α-androstane-3, 17-dione, 3α-hydroxy-5α-androstan-17-one, 3β-hydroxy-5α-androstan-17-dione, 17β-hydroxy-4-androsten-3-one, and 17β-hydroxy-5α-androstan-3-one with rat liver microsomes 18-hydroxy-4-androstene-3, 17-dione, 18-hydroxy-5α-androstane-3, 17-dione, 3α, 18-dihydroxy-5α-androstan-17-one, and 3β, 18-dihydroxy-5α-androstan-17-one have been isolated and identified by thin-layer chromatography and by gas chromatography-mass spectrometry. It is concluded that the liver may be an important extraadrenal site of 18-hydroxylation of steroids.

Original languageEnglish (US)
Pages (from-to)723-735
Number of pages13
Issue number6
StatePublished - Jun 1970

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry


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