Studies on the Metabolism of C19 Steroids in Rat Liver: 6α‐Hydroxylation of 3‐Oxo‐Δ4‐Steroids in Rat Liver Microsomes

Jan‐Åke Gustafsson, Belisário P. Lisboa

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

After incubation of testosterone and androstenedione with 105000μg microsomes of rat liver 6α‐hydroxytestosterone and 6α‐hydroxyandrostenedione, respectively, were isolated and identified by thin‐layer chromatography and gas chromatography‐mass spectrometry. This is the first example of 6α‐hydroxylation of steroid hormones in the rat and the findings are discussed in relation to earlier reports of 6α‐ and 6β‐hydroxylated steroids in mammalia.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalEuropean Journal of Biochemistry
Volume12
Issue number2
DOIs
StatePublished - Feb 1970

ASJC Scopus subject areas

  • Biochemistry

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