TY - JOUR
T1 - Studies on the Metabolism of C19 Steroids in Rat Liver
T2 - 6α‐Hydroxylation of 3‐Oxo‐Δ4‐Steroids in Rat Liver Microsomes
AU - Gustafsson, Jan‐Åke
AU - Lisboa, Belisário P.
PY - 1970/2
Y1 - 1970/2
N2 - After incubation of testosterone and androstenedione with 105000μg microsomes of rat liver 6α‐hydroxytestosterone and 6α‐hydroxyandrostenedione, respectively, were isolated and identified by thin‐layer chromatography and gas chromatography‐mass spectrometry. This is the first example of 6α‐hydroxylation of steroid hormones in the rat and the findings are discussed in relation to earlier reports of 6α‐ and 6β‐hydroxylated steroids in mammalia.
AB - After incubation of testosterone and androstenedione with 105000μg microsomes of rat liver 6α‐hydroxytestosterone and 6α‐hydroxyandrostenedione, respectively, were isolated and identified by thin‐layer chromatography and gas chromatography‐mass spectrometry. This is the first example of 6α‐hydroxylation of steroid hormones in the rat and the findings are discussed in relation to earlier reports of 6α‐ and 6β‐hydroxylated steroids in mammalia.
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U2 - 10.1111/j.1432-1033.1970.tb00860.x
DO - 10.1111/j.1432-1033.1970.tb00860.x
M3 - Article
C2 - 5459574
AN - SCOPUS:0014742849
VL - 12
SP - 369
EP - 374
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
SN - 0014-2956
IS - 2
ER -