Studies on the metabolism of C19 steroids in rat liver. 5. 18-hydroxylation of 17β-hydroxy-C19 steroids in rat liver microsomes

J. Å Gustafsson, B. P. Lisboa

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

After incubation of testosterone, 18-hydroxytestosterone and 5α-dihydrotestosterone with rat liver microsomes 17β,18-dihydroxy-5α-androstan-3-one, 5α-androstane-3α,17β,18-triol and 5α-androstane-3β,17β,18-triol have been isolated and characterized by thin-layer and gas-liquid chromatography and by gas chromatography-mass spectrometry. Furthermore, after incubation of 5α-dihydrotestosterone two androstanetetrols were isolated, the mass spectrometric characteristics of which indicate the presence of an 18-hydroxyl group.

Original languageEnglish (US)
Pages (from-to)659-674
Number of pages16
JournalSteroids
Volume14
Issue number6
DOIs
StatePublished - Dec 1969

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

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