Studies of the potential utility of Ki67 as a predictive molecular marker of clinical response in primary breast cancer

L. Assersohn, J. Salter, T. J. Powles, R. A'hern, A. Makris, R. K. Gregory, J. Chang, M. Dowsett

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Introduction. Objectives were to characterise the relationship of the proliferation marker Ki67 with response to systemic treatment in early breast cancer and to assess its clinical utility, using fine needle aspirates. Materials and methods. Hundred and six women were treated with primary tamoxifen (n = 33), chemotherapy (n = 33) or chemotherapy and tamoxifen (n = 40). Treatment was not randomised and response was assessed clinically. Ki67 was evaluated prior to treatment and at Day 14 or 21 after commencing treatment. To assess reproducibility, Ki67 was evaluated in repeat FNAs taken from 37 untreated patients. Results. The percentage change in Ki67 in first 21 days was different between responders and non-responders for patients treated with tamoxifen (p = 0.007) and chemotherapy (p = 0.005) but not for chemoendocrine treatment (p = 0.062). The reproducibility study indicated that a decrease to 36% or less of the pre-treatment Ki67 value in an individual patient was required for it to be regarded as a statistically significant change. A significant decrease in Ki67 was seen in responding patients treated with chemotherapy (p = 0.026) and chemoendocrine treatment (p = 0.041). Positive and negative predictive values for response were 85 and 59% for chemotherapy patients and 88 and 54% for chemoendocrine patients, respectively. Conclusion. Ki67 is unlikely to be useful as a predictive marker in individual patients. Further molecular markers that predict lack of response continue to be required.

Original languageEnglish (US)
Pages (from-to)113-123
Number of pages11
JournalBreast Cancer Research and Treatment
Volume82
Issue number2
DOIs
StatePublished - Nov 2003

Keywords

  • Breast cancer
  • Ki67
  • Marker
  • Predictive
  • Response

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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