Studies of Small Intestinal Myoelectrical Activity and Intraluminal Pressure Changes in the Unrestrained Conscious Rat

M. A. Arouni, J. Lof, D. L. Jacobs, L. F. Rikkers, Eamonn Martin Quigley

Research output: Contribution to journalArticle

Abstract

Our aim was to develop and validate a methodology to permit chronic recordings of small intestinal intraluminal pressure changes in the conscious rat and thereby to study regional variations in motor activity. A low‐flow (0.014 cc/min) perfusion system permitted reliable intraluminal pressure recordings at four sites along the small intestine from unrestrained animals. Comparison of overall patterns of fasted and fed motor activity and the various parameters of the migrating motor complex (MMC) from these recordings with those obtained from another group of animals prepared with serosal electrodes provided similar results in the proximal small intestine (MMC frequency 3.4 ± 0.5 vs. 3.9 ± 0.3 cycles/h, phase II duration 3.8 ± 0.7 vs. 4.7 ± 0.4 min, and phase III duration 4.0 ± 0.2 vs. 3.5 ± 0.2 min for duodenal catheters vs. electrodes, all NS). However, the distal deal phase II was considerably shorter in catheter than electrode recordings (6.0 ± 0.8 vs. 15.7 ± 2.4 min, p <0.0001). Both methodologies confirmed significant regional variations in small intestinal motor parameters: the incidence of interdigestive myoelectrical complex (IDMEC) cycles was lower and phase II of the IDMEC was considerably prolonged in the distal Hewn. In summary, a system to permit chronic recordings of small intestinal intraluminal pressure has been developed and validated by comparison to myoelectrical recordings. Motor specialization was evident in the rat distal ileum.

Original languageEnglish (US)
Pages (from-to)12-18
Number of pages7
JournalNeurogastroenterology and Motility
Volume3
Issue number1
DOIs
StatePublished - 1991

Keywords

  • ileum
  • intestinal motility
  • manometry
  • migrating motor complex
  • myoelectrical activity

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

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