Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes

J. M. Kim; C. I. Brannan; N. G. Copeland; N. A. Jenkins; T. A. Khan; K. W. Moore

Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes

J. M. Kim, C. I. Brannan, N. G. Copeland, N. A. Jenkins, T. A. Khan, K. W. Moore

Research output: Contribution to journal › Article › peer-review

Abstract

The nucleotide sequence of a 7.2-kb segment containing the mouse IL-10 (mIL-10) gene was determined. Comparison to the mIL-10 cDNA sequence (Moore, K. W., et al. 1990. Science 248:1230; 250:494) revealed the presence of five exons that span ∼5.1 kb of genomic DNA. The noncoding regions of the mIL-10 gene contain sequences that have been associated with transcriptional regulation of several cytokine genes. The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1.

Original language	English (US)
Pages (from-to)	3618-3623
Number of pages	6
Journal	Journal of Immunology
Volume	148
Issue number	11
State	Published - 1992

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

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title = "Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes",

abstract = "The nucleotide sequence of a 7.2-kb segment containing the mouse IL-10 (mIL-10) gene was determined. Comparison to the mIL-10 cDNA sequence (Moore, K. W., et al. 1990. Science 248:1230; 250:494) revealed the presence of five exons that span ∼5.1 kb of genomic DNA. The noncoding regions of the mIL-10 gene contain sequences that have been associated with transcriptional regulation of several cytokine genes. The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1.",

author = "Kim, {J. M.} and Brannan, {C. I.} and Copeland, {N. G.} and Jenkins, {N. A.} and Khan, {T. A.} and Moore, {K. W.}",

year = "1992",

language = "English (US)",

volume = "148",

pages = "3618--3623",

journal = "Journal of Immunology",

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T1 - Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes

AU - Kim, J. M.

AU - Brannan, C. I.

AU - Copeland, N. G.

AU - Jenkins, N. A.

AU - Khan, T. A.

AU - Moore, K. W.

PY - 1992

Y1 - 1992

N2 - The nucleotide sequence of a 7.2-kb segment containing the mouse IL-10 (mIL-10) gene was determined. Comparison to the mIL-10 cDNA sequence (Moore, K. W., et al. 1990. Science 248:1230; 250:494) revealed the presence of five exons that span ∼5.1 kb of genomic DNA. The noncoding regions of the mIL-10 gene contain sequences that have been associated with transcriptional regulation of several cytokine genes. The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1.

AB - The nucleotide sequence of a 7.2-kb segment containing the mouse IL-10 (mIL-10) gene was determined. Comparison to the mIL-10 cDNA sequence (Moore, K. W., et al. 1990. Science 248:1230; 250:494) revealed the presence of five exons that span ∼5.1 kb of genomic DNA. The noncoding regions of the mIL-10 gene contain sequences that have been associated with transcriptional regulation of several cytokine genes. The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1.

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AN - SCOPUS:0026549323

VL - 148

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EP - 3623

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 11

ER -

Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes

Abstract

ASJC Scopus subject areas

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