Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes

J. M. Kim, C. I. Brannan, Neal G. Copeland, Nancy A. Jenkins, T. A. Khan, K. W. Moore

Research output: Contribution to journalArticle

227 Scopus citations

Abstract

The nucleotide sequence of a 7.2-kb segment containing the mouse IL-10 (mIL-10) gene was determined. Comparison to the mIL-10 cDNA sequence (Moore, K. W., et al. 1990. Science 248:1230; 250:494) revealed the presence of five exons that span ∼5.1 kb of genomic DNA. The noncoding regions of the mIL-10 gene contain sequences that have been associated with transcriptional regulation of several cytokine genes. The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1.

Original languageEnglish (US)
Pages (from-to)3618-3623
Number of pages6
JournalJournal of Immunology
Volume148
Issue number11
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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