Abstract
Replacement of the single cysteine residue (C192) with serine in the Streptococcus pyogenes extracellular cysteine protease (SCP) prevented auto- catalytic processing of the 40-kDa zymogen to the 28-kDa mature form and eliminated proteolytic activity. SCP incubated with human endothelial cells induced a time- and concentration-dependent increase in a 66-kDa gelatinase/type IV collagenase in culture supernatants. Activation of this gelatinase/collagenase may contribute to endothelial cell damage, tissue destruction, and hemodynamic derangement observed in some patients with severe, invasive S. pyogenes infection.
Original language | English (US) |
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Pages (from-to) | 589-592 |
Number of pages | 4 |
Journal | Advances in experimental medicine and biology |
Volume | 418 |
DOIs | |
State | Published - 1997 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)