@article{a4cf82ae6ba84d01a9dff4ffd7136ede,
title = "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts",
abstract = "We have cloned and characterized LATS2, a novel mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Northern blot analysis showed ubiquitous expression of mouse LATS2 (MmLATS2) mRNA, whereas expression of human LATS2 (HsLATS2) mRNA was enhanced in skeletal muscle and heart. Immunoblotting analysis of fractionated cell lysates showed HsLats2 to be a nuclear protein. We mapped the MmLATS2 gene to mouse chromosome 14 by interspecific backcross analysis. We also mapped the HsLATS2 gene (by fluorescence in situ hybridization) to the 13q11-q12 region, in which a loss of heterozygosity has been frequently observed in many primary cancers and to which the tumor suppressor genes RB and BRCA2 have also been mapped. (C) 2000 Academic Press.",
author = "Norikazu Yabuta and Takayuki Fujii and Copeland, {Neal G.} and Gilbert, {Debra J.} and Jenkins, {Nancy A.} and Hiroaki Nishiguchi and Yuichi Endo and Shingo Toji and Hiromitsu Tanaka and Yoshitake Nishimune and Hiroshi Nojima",
note = "Funding Information: We thank Deborah Householder for excellent technical assistance in mouse chromosome mapping. We also thank Professor T. Yasu- naga for assistance in computer manipulation. This research was supported mainly by a Grant-in-aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports, and Culture of Japan. This research was also supported, in part, by the National Cancer Institute, DHHS, under contract with ABL. N.Y. was supported by JSPS Research Fellowships for Young Scientists. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2000",
month = jan,
day = "15",
doi = "10.1006/geno.1999.6065",
language = "English (US)",
volume = "63",
pages = "263--270",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press",
number = "2",
}