Structure, chromosome mapping and expression of the murine Fgf-6 gene

O. De Lapeyriere, O. Rosnet, D. Benharroch, F. Raybaud, S. Marchetto, J. Planche, F. Galland, M. G. Mattei, Neal G. Copeland, Nancy A. Jenkins, F. Coulier, D. Birnbaum

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

The sixth member of the fibroblast growth factor gene family was cloned and analysed in the mouse. It is composed of three coding exons and encodes a putative growth protein of 198 amino acids, possessing a potential signal peptide, and presenting 79% and 93.5% sequence similarity with the mouse Hst/K-fgf and human FGF-6 genes products, respectively. The murine Fgf-6 gene is located in a region distinct from the Int-41 locus and belongs to a linkage group conserved between chromosome 12 in man and chromosome 6 in mouse. It presents an intrinsic oncogenic capacity since it is able to transform cultured fibroblasts. Fgf-6 mRNA levels are developmentally regulated with a peak of expression in the developing fetus at day 15.5 of gestation, moderate levels during late gestation and in the neonate. In the adult, Fgf-6 mRNA can be detected in testis, heart and skeletal muscle.

Original languageEnglish (US)
Pages (from-to)823-831
Number of pages9
JournalOncogene
Volume5
Issue number6
StatePublished - Jun 27 1990

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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