Abstract
The G protein γ subunits are members of a multigene family and are implicated in determining the specificity of receptor-G protein interaction. The gene structures for many of the γ subunits remain to be determined. Here, we report the gene structure for the brain-specific γ4 subunit and its map position on a mouse chromosome. The gene (Gng4) comprises at least three exons spanning over 20 kb. The 225-bp coding region, which spans two exons, is interrupted by a large 18.2-kb intron whose position is conserved in other γ subunit genes. There is a putative additional intron in the 5' untranslated region just upstream of the translation initiation codon. Introns are present in most of the other γ subunits at this position. The mouse Gng4 gene is mapped to chromosome 13.
Original language | English (US) |
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Pages (from-to) | 147-151 |
Number of pages | 5 |
Journal | Genomics |
Volume | 49 |
Issue number | 1 |
DOIs | |
State | Published - Apr 1 1998 |
ASJC Scopus subject areas
- Genetics