Abstract
We previously reported the antibacterial activity of CD437, a known antitumor compound. It proved to be a potent antimicrobial agent effective against both growing and persister cells of methicillin-resistant Staphylococcus aureus (MRSA). Herein, we report the synthesis of a panel of analogs and their effect on both MRSA and cancer cells. The hydrophobic group of the parent compound was varied in steric bulk, and lipid-mimicking analogs were tested. Biological assessment confirmed that the adamantane moiety is the most effective substitution for antibacterial activity, and some preferential action in cancer over MRSA was achieved.
Original language | English (US) |
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Pages (from-to) | 393-397 |
Number of pages | 5 |
Journal | ACS Medicinal Chemistry Letters |
Volume | 11 |
Issue number | 3 |
DOIs | |
State | Published - Mar 12 2020 |
Keywords
- CD437
- Methicillin resistant Staphylococcus aureus
- cancer
- persister
- retinoid
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry