TY - JOUR
T1 - Structural and regulatory analysis of the male-specific rat liver cytochrome P-450 g
T2 - Repression by continuous growth hormone administration
AU - Zaphiropoulos, Peter G.
AU - Ström, Anders
AU - Robertson, John A.
AU - Gustafsson, Jan Ake
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1990/1
Y1 - 1990/1
N2 - Complementary DNA clones encoding the male-specific rat liver cytochrome P-450 g have been isolated by cross-hybridization with sequences from the female-specific rat liver cytochrome P-450 15β. Tissue distribution analysis indicates the liver as the organ with major expression of this cytochrome P-450 gene. Minimal P-450 g expression was also detected in prostate, kidney, heart, and brain. A developmental analysis reveals liver expression in the 8-week-old male and to a lesser extent in the 4-week-old male, but no detectable expression is seen in females of these ages or in 1- and 2-week-old rats from both sexes. Hypophysectomy of female rats dramatically increases hepatic expression of P-450 g, whereas continuous GH administration represses hepatic expression in male or female hypophysectomized rats. In similarity to P-450 15β and P-450 16α, therefore, the cytochrome P-450 g gene in liver is GH regulated.
AB - Complementary DNA clones encoding the male-specific rat liver cytochrome P-450 g have been isolated by cross-hybridization with sequences from the female-specific rat liver cytochrome P-450 15β. Tissue distribution analysis indicates the liver as the organ with major expression of this cytochrome P-450 gene. Minimal P-450 g expression was also detected in prostate, kidney, heart, and brain. A developmental analysis reveals liver expression in the 8-week-old male and to a lesser extent in the 4-week-old male, but no detectable expression is seen in females of these ages or in 1- and 2-week-old rats from both sexes. Hypophysectomy of female rats dramatically increases hepatic expression of P-450 g, whereas continuous GH administration represses hepatic expression in male or female hypophysectomized rats. In similarity to P-450 15β and P-450 16α, therefore, the cytochrome P-450 g gene in liver is GH regulated.
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U2 - 10.1210/mend-4-1-53
DO - 10.1210/mend-4-1-53
M3 - Article
C2 - 2325668
AN - SCOPUS:0025176602
VL - 4
SP - 53
EP - 58
JO - Molecular Endocrinology
JF - Molecular Endocrinology
SN - 0888-8809
IS - 1
ER -