TY - JOUR
T1 - Stress, inflammation and hippocampal subfields in depression
T2 - A 7 Tesla MRI Study
AU - Tannous, Jonika
AU - Godlewska, Beata R.
AU - Tirumalaraju, Vaishali
AU - Soares, Jair C.
AU - Cowen, Phil J.
AU - Selvaraj, Sudhakar
N1 - Funding Information:
S.S. has received speaking honoraria from Global Medical Education and honoraria from British Medical Journal Publishing Group; own shares at Flow Med Tech; Research support from Compass pathways. P.J.C has no conflicting interests during the last 3 years. B.R.G. has received travel expenses from Janssen UK. P.J.C. has no conflict of interest. J.C.S. has received grants/research support from BMS, Forrest, J&J, Merck, Compass pathways, Stanley Medical Research Institute, NIH and has been a speaker for Pfizer and Abbott. J.T. has no conflict of interest.
Funding Information:
This work was supported by an MRC program grant to P.J.C. (MR/K022202/1) and the Oxford Health NIHR Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the National Health Service, NIHR or the Department of Health. We thank all the participants, as well as Jon Campbell, David Parker, Michael Sanders and Caroline Young for expert radiographic assistance, and care of the participants during scanning. Anonymized individual subject data are available at the Open Source Framework: osf.io/2cwya/
Publisher Copyright:
© 2020, The Author(s).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Experiencing stressful events throughout one’s life, particularly childhood trauma, increases the likelihood of being diagnosed with Major Depressive Disorder (MDD). Raised levels of cortisol, and markers of inflammation such as Interleukin (IL-6) and C-reactive protein (CRP), have been linked to both early life stress and MDD. We aimed to explore the biological stress signatures of early stress and MDD on hippocampal sub regional volumes using 7 Tesla MRI imaging. A cohort of 71 MDD patients was compared against 46 age and sex-matched healthy volunteers. MDD subjects had higher averages of IL-6 and CRP levels. These differences were significant for IL-6 levels and trended for CRP. There were no significant group differences in any of the hippocampal subfields or global hippocampal volumes; further, there were no hippocampal subfield differences between MDD subjects with high levels of our biological stress measures and MDDs with normal levels.
AB - Experiencing stressful events throughout one’s life, particularly childhood trauma, increases the likelihood of being diagnosed with Major Depressive Disorder (MDD). Raised levels of cortisol, and markers of inflammation such as Interleukin (IL-6) and C-reactive protein (CRP), have been linked to both early life stress and MDD. We aimed to explore the biological stress signatures of early stress and MDD on hippocampal sub regional volumes using 7 Tesla MRI imaging. A cohort of 71 MDD patients was compared against 46 age and sex-matched healthy volunteers. MDD subjects had higher averages of IL-6 and CRP levels. These differences were significant for IL-6 levels and trended for CRP. There were no significant group differences in any of the hippocampal subfields or global hippocampal volumes; further, there were no hippocampal subfield differences between MDD subjects with high levels of our biological stress measures and MDDs with normal levels.
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U2 - 10.1038/s41398-020-0759-0
DO - 10.1038/s41398-020-0759-0
M3 - Article
C2 - 32098947
AN - SCOPUS:85081073996
VL - 10
JO - Translational Psychiatry
JF - Translational Psychiatry
SN - 2158-3188
IS - 1
M1 - 78
ER -