Streptococcus pyogenes and human neutrophils: A paradigm for evasion of innate host defense by bacterial pathogens

Jovanka M. Voyich; James M. Musser; Frank R. DeLeo

doi:10.1016/j.micinf.2004.05.022

Streptococcus pyogenes and human neutrophils: A paradigm for evasion of innate host defense by bacterial pathogens

Jovanka M. Voyich, James M. Musser, Frank R. DeLeo

Research output: Contribution to journal › Short survey › peer-review

58 Scopus citations

Abstract

Human polymorphonuclear leukocytes (PMNs) are the first line of defense against invading microorganisms. Although most invading bacteria are eliminated by PMNs, some have evolved complex strategies to prevent normal PMN function. This review focuses on the interaction of human PMNs with Streptococcus pyogenes as a paradigm for successful pathogen evasion mechanisms.

Original language	English (US)
Pages (from-to)	1117-1123
Number of pages	7
Journal	Microbes and Infection
Volume	6
Issue number	12
DOIs	https://doi.org/10.1016/j.micinf.2004.05.022
State	Published - Oct 2004

Keywords

Apoptosis
Innate immunity
Neutrophils
Phagocytosis
Polymorphonuclear leukocytes
Streptococcus pyogenes

ASJC Scopus subject areas

Microbiology
Infectious Diseases

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10.1016/j.micinf.2004.05.022

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title = "Streptococcus pyogenes and human neutrophils: A paradigm for evasion of innate host defense by bacterial pathogens",

abstract = "Human polymorphonuclear leukocytes (PMNs) are the first line of defense against invading microorganisms. Although most invading bacteria are eliminated by PMNs, some have evolved complex strategies to prevent normal PMN function. This review focuses on the interaction of human PMNs with Streptococcus pyogenes as a paradigm for successful pathogen evasion mechanisms.",

keywords = "Apoptosis, Innate immunity, Neutrophils, Phagocytosis, Polymorphonuclear leukocytes, Streptococcus pyogenes",

author = "Voyich, \{Jovanka M.\} and Musser, \{James M.\} and DeLeo, \{Frank R.\}",

year = "2004",

month = oct,

doi = "10.1016/j.micinf.2004.05.022",

language = "English (US)",

volume = "6",

pages = "1117--1123",

journal = "Microbes and Infection",

issn = "1286-4579",

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number = "12",

}

TY - JOUR

T1 - Streptococcus pyogenes and human neutrophils

T2 - A paradigm for evasion of innate host defense by bacterial pathogens

AU - Voyich, Jovanka M.

AU - Musser, James M.

AU - DeLeo, Frank R.

PY - 2004/10

Y1 - 2004/10

N2 - Human polymorphonuclear leukocytes (PMNs) are the first line of defense against invading microorganisms. Although most invading bacteria are eliminated by PMNs, some have evolved complex strategies to prevent normal PMN function. This review focuses on the interaction of human PMNs with Streptococcus pyogenes as a paradigm for successful pathogen evasion mechanisms.

AB - Human polymorphonuclear leukocytes (PMNs) are the first line of defense against invading microorganisms. Although most invading bacteria are eliminated by PMNs, some have evolved complex strategies to prevent normal PMN function. This review focuses on the interaction of human PMNs with Streptococcus pyogenes as a paradigm for successful pathogen evasion mechanisms.

KW - Apoptosis

KW - Innate immunity

KW - Neutrophils

KW - Phagocytosis

KW - Polymorphonuclear leukocytes

KW - Streptococcus pyogenes

UR - https://www.scopus.com/pages/publications/4544297298

UR - https://www.scopus.com/inward/citedby.url?scp=4544297298&partnerID=8YFLogxK

U2 - 10.1016/j.micinf.2004.05.022

DO - 10.1016/j.micinf.2004.05.022

M3 - Short survey

C2 - 15380782

AN - SCOPUS:4544297298

SN - 1286-4579

VL - 6

SP - 1117

EP - 1123

JO - Microbes and Infection

JF - Microbes and Infection

IS - 12

ER -

Streptococcus pyogenes and human neutrophils: A paradigm for evasion of innate host defense by bacterial pathogens

Abstract

Keywords

ASJC Scopus subject areas

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