Streptococcus pyogenes and human neutrophils: A paradigm for evasion of innate host defense by bacterial pathogens

Jovanka M. Voyich, James M. Musser, Frank R. DeLeo

Research output: Contribution to journalShort survey

50 Scopus citations

Abstract

Human polymorphonuclear leukocytes (PMNs) are the first line of defense against invading microorganisms. Although most invading bacteria are eliminated by PMNs, some have evolved complex strategies to prevent normal PMN function. This review focuses on the interaction of human PMNs with Streptococcus pyogenes as a paradigm for successful pathogen evasion mechanisms.

Original languageEnglish (US)
Pages (from-to)1117-1123
Number of pages7
JournalMicrobes and Infection
Volume6
Issue number12
DOIs
StatePublished - Jan 1 2004

Keywords

  • Apoptosis
  • Innate immunity
  • Neutrophils
  • Phagocytosis
  • Polymorphonuclear leukocytes
  • Streptococcus pyogenes

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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