Streptococcus pneumoniae serotypes in Utah adults at the end of the PCV7 era

Brian A. Kendall; Kristin K. Dascomb; Rajesh R. Mehta; Edward O. Mason; Krow Ampofo; David J. Pombo; Andrew T. Pavia; Carrie L. Byington

doi:10.1016/j.vaccine.2011.10.009

Streptococcus pneumoniae serotypes in Utah adults at the end of the PCV7 era

Brian A. Kendall, Kristin K. Dascomb, Rajesh R. Mehta, Edward O. Mason, Krow Ampofo, David J. Pombo, Andrew T. Pavia, Carrie L. Byington

Houston Methodist

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

While heptavalent pneumococcal conjugate vaccine (PCV) has decreased vaccine type invasive pneumococcal disease (IPD) nationwide, rapid serotype replacement and increasing parapneumonic empyema, has been reported in Utah children. The effect of pediatric vaccination on adults in this population is unknown.We identified 117 adults with IPD from the Intermountain Healthcare Central Laboratory between November 2009 and October 2010. We serotyped 61 (52%) stored isolates. We compared the serotype distribution of adult IPD isolates with that of pediatric isolates collected in 2009-2010.PCV7 serotypes were rare in adults (3%) and children (3%). Emerging 13-valent PCV serotypes 3, 7F, and 19A caused the majority of IPD in adults (63%) and children (56%). Fifty-one (84%) adult isolates were serotypes included in 23-valent polysaccharide vaccine and 66% in PCV13.Adult and pediatric IPD serotypes are closely associated in Utah. PCV13 vaccination in Utah children is likely to significantly impact IPD in Utah adults.

Original language	English (US)
Pages (from-to)	9123-9126
Number of pages	4
Journal	Vaccine
Volume	29
Issue number	49
DOIs	https://doi.org/10.1016/j.vaccine.2011.10.009
State	Published - Nov 15 2011

Keywords

Bacteremia
Invasive pneumococcal disease
Pneumonia
Serotype
Streptococcus pneumoniae

ASJC Scopus subject areas

General Immunology and Microbiology
Infectious Diseases
Public Health, Environmental and Occupational Health
General Veterinary
Molecular Medicine

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10.1016/j.vaccine.2011.10.009

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title = "Streptococcus pneumoniae serotypes in Utah adults at the end of the PCV7 era",

abstract = "While heptavalent pneumococcal conjugate vaccine (PCV) has decreased vaccine type invasive pneumococcal disease (IPD) nationwide, rapid serotype replacement and increasing parapneumonic empyema, has been reported in Utah children. The effect of pediatric vaccination on adults in this population is unknown.We identified 117 adults with IPD from the Intermountain Healthcare Central Laboratory between November 2009 and October 2010. We serotyped 61 (52%) stored isolates. We compared the serotype distribution of adult IPD isolates with that of pediatric isolates collected in 2009-2010.PCV7 serotypes were rare in adults (3%) and children (3%). Emerging 13-valent PCV serotypes 3, 7F, and 19A caused the majority of IPD in adults (63%) and children (56%). Fifty-one (84%) adult isolates were serotypes included in 23-valent polysaccharide vaccine and 66% in PCV13.Adult and pediatric IPD serotypes are closely associated in Utah. PCV13 vaccination in Utah children is likely to significantly impact IPD in Utah adults.",

keywords = "Bacteremia, Invasive pneumococcal disease, Pneumonia, Serotype, Streptococcus pneumoniae",

author = "Kendall, {Brian A.} and Dascomb, {Kristin K.} and Mehta, {Rajesh R.} and Mason, {Edward O.} and Krow Ampofo and Pombo, {David J.} and Pavia, {Andrew T.} and Byington, {Carrie L.}",

note = "Funding Information: Brian Kendall received salary support from the Department of Infectious Diseases, Intermountain Medical Center . Dr. Byington is supported in part through a Public Health Services research grant UL1-RR025764 from the National Center for Research Resources . ",

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AU - Ampofo, Krow

AU - Pombo, David J.

AU - Pavia, Andrew T.

AU - Byington, Carrie L.

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N2 - While heptavalent pneumococcal conjugate vaccine (PCV) has decreased vaccine type invasive pneumococcal disease (IPD) nationwide, rapid serotype replacement and increasing parapneumonic empyema, has been reported in Utah children. The effect of pediatric vaccination on adults in this population is unknown.We identified 117 adults with IPD from the Intermountain Healthcare Central Laboratory between November 2009 and October 2010. We serotyped 61 (52%) stored isolates. We compared the serotype distribution of adult IPD isolates with that of pediatric isolates collected in 2009-2010.PCV7 serotypes were rare in adults (3%) and children (3%). Emerging 13-valent PCV serotypes 3, 7F, and 19A caused the majority of IPD in adults (63%) and children (56%). Fifty-one (84%) adult isolates were serotypes included in 23-valent polysaccharide vaccine and 66% in PCV13.Adult and pediatric IPD serotypes are closely associated in Utah. PCV13 vaccination in Utah children is likely to significantly impact IPD in Utah adults.

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KW - Serotype

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Streptococcus pneumoniae serotypes in Utah adults at the end of the PCV7 era

Abstract

Keywords

ASJC Scopus subject areas

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