TY - JOUR
T1 - Streptococcus mitis strains causing severe clinical disease in cancer patients
AU - Shelburne, Samuel
AU - Sahasrabhojane, Pranoti
AU - Saldana, Miguel
AU - Yao, Hui
AU - Su, Xiaoping
AU - Horstmann, Nicola
AU - Thompson, Erika
AU - Flores, Anthony R.
PY - 2014/5
Y1 - 2014/5
N2 - The genetically diverse viridans group streptococci (VGS) are increasingly recognized as the cause of a variety of human diseases. We used a recently developed multilocus sequence analysis scheme to define the species of 118 unique VGS strains causing bacteremia in patients with cancer; Streptococcus mitis (68 patients) and S. oralis (22 patients) were the most frequently identified strains. Compared with patients infected with non-S. mitis strains, patients infected with S. mitis strains were more likely to have moderate or severe clinical disease (e.g., VGS shock syndrome). Combined with the sequence data, whole-genome analyses showed that S. mitis strains may more precisely be considered as ≥2 species. Furthermore, we found that multiple S. mitis strains induced disease in neutropenic mice in a dose-dependent fashion. Our data define the prominent clinical effect of the group of organisms currently classified as S. mitis and lay the groundwork for increased understanding of this understudied pathogen.
AB - The genetically diverse viridans group streptococci (VGS) are increasingly recognized as the cause of a variety of human diseases. We used a recently developed multilocus sequence analysis scheme to define the species of 118 unique VGS strains causing bacteremia in patients with cancer; Streptococcus mitis (68 patients) and S. oralis (22 patients) were the most frequently identified strains. Compared with patients infected with non-S. mitis strains, patients infected with S. mitis strains were more likely to have moderate or severe clinical disease (e.g., VGS shock syndrome). Combined with the sequence data, whole-genome analyses showed that S. mitis strains may more precisely be considered as ≥2 species. Furthermore, we found that multiple S. mitis strains induced disease in neutropenic mice in a dose-dependent fashion. Our data define the prominent clinical effect of the group of organisms currently classified as S. mitis and lay the groundwork for increased understanding of this understudied pathogen.
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U2 - 10.3201/eid2005.130953
DO - 10.3201/eid2005.130953
M3 - Article
C2 - 24750901
AN - SCOPUS:84898846252
SN - 1080-6040
VL - 20
SP - 762
EP - 771
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 5
ER -