Strategies for targeting the DNA damage respones for cancer therapeutics

Dan Zhang, Hai Bo Wang, Kathryn L. Brinkman, Su Xia Han, Bo Xu

Research output: Contribution to journalEditorial

5 Scopus citations

Abstract

The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.

Original languageEnglish (US)
Pages (from-to)359-363
Number of pages5
JournalChinese journal of cancer
Volume31
Issue number8
DOIs
StatePublished - Jun 14 2012
Externally publishedYes

Keywords

  • DNA damage response
  • DNA repair
  • PARP inhibitors
  • Synthetic lethality

ASJC Scopus subject areas

  • Oncology

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