TY - JOUR
T1 - Stevens-Johnson syndrome
T2 - Pathogenesis, diagnosis, and management
AU - Hazin, Ribhi
AU - Ibrahimi, Omar A.
AU - Hazin, Moustafa I.
AU - Kimyai-Asadi, Arash
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - Cutaneous drug reactions are the most common type of adverse drug reaction. These reactions, ranging from simple pruritic eruptions to potentially life-threatening events, are a significant cause of iatrogenic morbidity and mortality. Stevens-Johnson syndrome (SJS) is a serious and potentially life-threatening cutaneous drug reaction. Although progress has been made in the management of SJS through early detection, prompt hospitalization, and immediate cessation of offending agents, the prevalence of permanent disabilities associated with SJS remains unchanged. Nevertheless, despite being a problem that is global in scope, government and health care agencies worldwide have yet to find a consensus on either diagnostic criteria or therapy for this disorder. Here, we provide the internist and emergency room physician with a brief review the SJS literature and summarize the latest recommended interventions with the hope of improving early recognition of this disease and prevention of permanent sequelae and mortality that frequently complicate SJS.
AB - Cutaneous drug reactions are the most common type of adverse drug reaction. These reactions, ranging from simple pruritic eruptions to potentially life-threatening events, are a significant cause of iatrogenic morbidity and mortality. Stevens-Johnson syndrome (SJS) is a serious and potentially life-threatening cutaneous drug reaction. Although progress has been made in the management of SJS through early detection, prompt hospitalization, and immediate cessation of offending agents, the prevalence of permanent disabilities associated with SJS remains unchanged. Nevertheless, despite being a problem that is global in scope, government and health care agencies worldwide have yet to find a consensus on either diagnostic criteria or therapy for this disorder. Here, we provide the internist and emergency room physician with a brief review the SJS literature and summarize the latest recommended interventions with the hope of improving early recognition of this disease and prevention of permanent sequelae and mortality that frequently complicate SJS.
KW - Adverse drug reaction
KW - Dermatological emergencies
KW - Drug hypersensitivity
KW - Erythema multiforme
KW - HLA B1501/HLA B1502
KW - Intravenous immunoglobulins
KW - Keratinocyte apoptosis
KW - Mucocutaneous lesions
KW - Stevens-Johnson syndrome
KW - Toxic epidermal necrolysis
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U2 - 10.1080/07853890701753664
DO - 10.1080/07853890701753664
M3 - Review article
C2 - 18293143
AN - SCOPUS:43149088950
SN - 0785-3890
VL - 40
SP - 129
EP - 138
JO - Annals of Medicine
JF - Annals of Medicine
IS - 2
ER -