TY - JOUR
T1 - Steroid-resistant acute rejection after cadaveric liver transplantation
T2 - Experience from one single center
AU - Wu, Linwei
AU - Tam, Ngalei
AU - Deng, Ronghai
AU - Wu, Chenglin
AU - Chen, Philip
AU - Wang, Dongping
AU - He, Xiaoshun
N1 - Funding Information:
This study was supported by the National Natural Science Foundation of China (No. 81102245 ) and Science and Technology Planning Project of Guangdong Province , China (No. 2011B0318000099 ) and Youth teachers cultivation project of Sun Yat-Sen University (No. 12ykpy21 ).
Publisher Copyright:
© 2014 Elsevier Masson SAS.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Background and objectives: Steroid-resistant acute rejection (SRAR) is an infrequent event under current immunosuppressant but still a risk factor leading to graft loss and patients' death after liver transplantation. There are several strategies for managing this complication according to current literatures, but none of the treatment seems convincing and widely accepted. Here we retrospectively analyzed the clinical data of a cohort of patients to gain an insight into this complication. Materials and methods: A total of 962 adult patients receiving whole liver grafts at a single center between January 2004 and December 2012 were studied. One hundred and forty-two recipients experienced 158 episodes of acute rejection after the operation, 14 recipients had no response to steroid bolus treatment. The clinical data was analyzed retrospectively. Results: Incidence rate of acute rejection after liver transplant in our single center was 14.7% (142/962), among them 8.8% (14/158) were steroid-resistant. These episodes occurred on 19. days (6-72. days) after the operation, 3 were controlled by anti-T3-receptor antibody (OKT3) treatment, 4 were reversed by IL-2 receptor inhibitors combining with MMF treatment, 2 were reversed by antithymocyte globulin (ATG) treatment. Five did not recover and 2 received retransplantation. Mortality associated with SRAR was 28.6% (4/14, 1 died from acute liver failure, 1 from chronic liver failure, 1 from renal failure after retransplantation and 1 from pulmonary infection after OKT3 treatment). Conclusion: SRAR is a severe complication with high mortality after liver transplantation; ATG might serve as a potential treatment.
AB - Background and objectives: Steroid-resistant acute rejection (SRAR) is an infrequent event under current immunosuppressant but still a risk factor leading to graft loss and patients' death after liver transplantation. There are several strategies for managing this complication according to current literatures, but none of the treatment seems convincing and widely accepted. Here we retrospectively analyzed the clinical data of a cohort of patients to gain an insight into this complication. Materials and methods: A total of 962 adult patients receiving whole liver grafts at a single center between January 2004 and December 2012 were studied. One hundred and forty-two recipients experienced 158 episodes of acute rejection after the operation, 14 recipients had no response to steroid bolus treatment. The clinical data was analyzed retrospectively. Results: Incidence rate of acute rejection after liver transplant in our single center was 14.7% (142/962), among them 8.8% (14/158) were steroid-resistant. These episodes occurred on 19. days (6-72. days) after the operation, 3 were controlled by anti-T3-receptor antibody (OKT3) treatment, 4 were reversed by IL-2 receptor inhibitors combining with MMF treatment, 2 were reversed by antithymocyte globulin (ATG) treatment. Five did not recover and 2 received retransplantation. Mortality associated with SRAR was 28.6% (4/14, 1 died from acute liver failure, 1 from chronic liver failure, 1 from renal failure after retransplantation and 1 from pulmonary infection after OKT3 treatment). Conclusion: SRAR is a severe complication with high mortality after liver transplantation; ATG might serve as a potential treatment.
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U2 - 10.1016/j.clinre.2014.04.005
DO - 10.1016/j.clinre.2014.04.005
M3 - Article
C2 - 24928711
AN - SCOPUS:84912522207
SN - 2210-7401
VL - 38
SP - 592
EP - 597
JO - Clinics and Research in Hepatology and Gastroenterology
JF - Clinics and Research in Hepatology and Gastroenterology
IS - 5
ER -