Steroid receptors in metastatic carcinoma of the human prostate

Peter Ekman, Marek Snochowski, Erik Dahlberg, Jan Åke Gustafsson

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Using a dextran-coated charcoal technique and isoelectric focusing in polyacrylamide gel, metastases from five patients with prostatic carcinoma were analysed for contents of cytosolic androgen, progestin, estrogen and glucocorticoid receptors. Maximum binding capacity (Bmax) and dissociation constant (Kd) were calculated from Scatchard plots. In three cases the patients had received endocrine therapy prior to removal of the specimen. Androgen and progestin receptors were measurable in 4 5 and 2 5 cases, respectively; no specimen contained estrogen receptors. In 3 5 cases large amounts of glucocorticoid receptors were detected.

Original languageEnglish (US)
Pages (from-to)257-262
Number of pages6
JournalEuropean Journal of Cancer (1965)
Volume15
Issue number2
DOIs
StatePublished - Feb 1979

ASJC Scopus subject areas

  • Medicine(all)

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