Steroid monosulfates in urine from male rat pseudohermaphrodites

Jan Ake Gustafsson; Allen S. Goldman

doi:10.1210/endo-90-4-931

Steroid monosulfates in urine from male rat pseudohermaphrodites

Jan Ake Gustafsson, Allen S. Goldman

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9 Scopus citations

Abstract

The excretion of steroid monosulfates in urine from female, male and male pseudohermaphrodites of the same strain of King X-Holtzman rats was studied by gas chromatography—mass spectrometry. Female rats excreted C₁₉O₃ and C₂₁O₃ steroids of ovarian origin and C₂₁O₄ and C₂₁O₅ steroids of adrenal origin. No steroid monosulfates were found in urine from male rats. Male pseudohermaphrodites excreted C₁₉O₃ C₂₁O₄ and C₂₁O₅ steroids identical to the corresponding steroids in the female rat; however, no C₂₁O₃ steroids were found in urine from male pseudohermaphrodites. The present results show that the hepatic metabolism of steroids in male pseudohermaphrodites has a female character.

Original language	English (US)
Pages (from-to)	931-935
Number of pages	5
Journal	Endocrinology
Volume	90
Issue number	4
DOIs	https://doi.org/10.1210/endo-90-4-931
State	Published - Apr 1972

ASJC Scopus subject areas

Endocrinology

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title = "Steroid monosulfates in urine from male rat pseudohermaphrodites",

abstract = "The excretion of steroid monosulfates in urine from female, male and male pseudohermaphrodites of the same strain of King X-Holtzman rats was studied by gas chromatography—mass spectrometry. Female rats excreted C19O3 and C21O3 steroids of ovarian origin and C21O4 and C21O5 steroids of adrenal origin. No steroid monosulfates were found in urine from male rats. Male pseudohermaphrodites excreted C19O3 C21O4 and C21O5 steroids identical to the corresponding steroids in the female rat; however, no C21O3 steroids were found in urine from male pseudohermaphrodites. The present results show that the hepatic metabolism of steroids in male pseudohermaphrodites has a female character.",

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AB - The excretion of steroid monosulfates in urine from female, male and male pseudohermaphrodites of the same strain of King X-Holtzman rats was studied by gas chromatography—mass spectrometry. Female rats excreted C19O3 and C21O3 steroids of ovarian origin and C21O4 and C21O5 steroids of adrenal origin. No steroid monosulfates were found in urine from male rats. Male pseudohermaphrodites excreted C19O3 C21O4 and C21O5 steroids identical to the corresponding steroids in the female rat; however, no C21O3 steroids were found in urine from male pseudohermaphrodites. The present results show that the hepatic metabolism of steroids in male pseudohermaphrodites has a female character.

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