Stereotactic body radiation therapy for medically inoperable early-stage lung cancer patients

Mirna Abboud, Bin S. Teh, Shanda H. Blackmon, Min Kim, Angel I. Blanco, Daniel Y. Lee, Jose F. Santacruz, Arnold Paulino, Edward Brian Butler, Nina A. Mayr, Zhibin Huang, Simon S. Lo

Research output: Contribution to journalArticle

Abstract

Lung cancer is the leading cause of cancer deaths in the United States. Only a small percentage of patients with non-small cell lung cancer present with early-stage disease. The standard curative treatment is lobectomy but patients with lung cancer frequently have comorbidities, rendering them unsuitable for surgical resection. Conventional radiotherapy has been used as a nonsurgical alternative for patients with early-stage non-small cell lung cancer but the outcomes are inferior to surgical resection. Stereotactic body radiation therapy (SBRT) has emerged as a promising treatment for medically inoperable early-stage non-small cell lung cancer with local control rates exceeding 90%, rivaling surgical resection. Multiple retrospective studies and prospective trials across the world have consistently demonstrated high local control rates and low rates of severe toxicities. Currently, multiple phase II and randomized phase III trials are ongoing, attempting to determine optimal SBRT regimen for different clinical scenarios and to compare SBRT with surgery.

Original languageEnglish (US)
Pages (from-to)289-294
Number of pages6
JournalClinical Pulmonary Medicine
Volume19
Issue number6
DOIs
StatePublished - Nov 2012

Keywords

  • lung cancer
  • medically inoperable
  • stereotactic body radiation therapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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