Stem cell neural differentiation: A model for chemical biology

Robert Krencik; Su-Chun Zhang

doi:10.1016/j.cbpa.2006.10.002

Stem cell neural differentiation: A model for chemical biology

Robert Krencik, Su-Chun Zhang

Research Institute

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Stem cells can produce progenies that constitute an organism or a tissue while replenishing (renewing) themselves. The ability to produce large quantities of stage-specific cells from self-renewing stem cells in a precisely controlled manner makes it possible to dissect out complex interactions among macromolecules along development, such as early brain development at the global level. These cellular differentiation pathways also serve as templates for identifying biological effects of novel or existing chemical compounds. Thus, stem cells find their most powerful use in chemical biology, which may ultimately lead to applications in regenerative medicine.

Original language	English (US)
Pages (from-to)	592-7
Number of pages	6
Journal	Current Opinion in Chemical Biology
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/j.cbpa.2006.10.002
State	Published - Dec 2006

Keywords

Cell Differentiation
Neurons
Stem Cells
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

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10.1016/j.cbpa.2006.10.002

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title = "Stem cell neural differentiation: A model for chemical biology",

abstract = "Stem cells can produce progenies that constitute an organism or a tissue while replenishing (renewing) themselves. The ability to produce large quantities of stage-specific cells from self-renewing stem cells in a precisely controlled manner makes it possible to dissect out complex interactions among macromolecules along development, such as early brain development at the global level. These cellular differentiation pathways also serve as templates for identifying biological effects of novel or existing chemical compounds. Thus, stem cells find their most powerful use in chemical biology, which may ultimately lead to applications in regenerative medicine.",

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T2 - A model for chemical biology

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AU - Zhang, Su-Chun

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AB - Stem cells can produce progenies that constitute an organism or a tissue while replenishing (renewing) themselves. The ability to produce large quantities of stage-specific cells from self-renewing stem cells in a precisely controlled manner makes it possible to dissect out complex interactions among macromolecules along development, such as early brain development at the global level. These cellular differentiation pathways also serve as templates for identifying biological effects of novel or existing chemical compounds. Thus, stem cells find their most powerful use in chemical biology, which may ultimately lead to applications in regenerative medicine.

KW - Cell Differentiation

KW - Neurons

KW - Stem Cells

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1016/j.cbpa.2006.10.002

DO - 10.1016/j.cbpa.2006.10.002

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JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

IS - 6

ER -

Stem cell neural differentiation: A model for chemical biology

Abstract

Keywords

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