Statins and hepatitis C virus infection: An old therapy with new scope

Fadi Rzouq, Fares Alahdab, Mojtaba Olyaee

    Research output: Contribution to journalReview articlepeer-review

    7 Scopus citations

    Abstract

    Although their safety and efficacy have been extensively demonstrated, significant underutilization of statins is frequently seen in clinical practice for fears of hepatotoxicity. Research has not only shown statins' safety in patients with various forms of liver disease but also revealed the great benefits conferred by such therapy among liver disease patients. Chronic hepatitis C virus (HCV) infection is not an exception. In fact, evidence has pointed to a dysmetabolic syndrome in HCV-infected patients, which places them at an increased risk for cardiovascular disease and makes statins a life-saving therapy with excellent efficacy. Furthermore, statins have shown anti-HCV proliferative effects and other beneficial roles in different aspects of liver health, making them excellent drugs with minimal risks. In this review, we have discussed the newly described dysmetabolic syndrome associated with HCV infection, statins safety and efficacy in patients with chronic liver disease with special emphasis on HCV patients, the anti-HCVproliferative effects of statins and finally, the benefits of statin therapy in other aspects of chronic liver disease.

    Original languageEnglish (US)
    Pages (from-to)426-430
    Number of pages5
    JournalAmerican Journal of the Medical Sciences
    Volume348
    Issue number5
    DOIs
    StatePublished - 2014

    Keywords

    • Dysmetabolic syndrome
    • Efficacy and safety
    • Hepatitis C virus
    • Hepatotoxicity
    • Statins

    ASJC Scopus subject areas

    • Medicine(all)

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