Statin use is associated with decreased risk of invasive mechanical ventilation in COVID-19 patients: A preliminary study

Sophia L. Song, Sarah B. Hays, Constance E. Panton, Evangelia K. Mylona, Markos Kalligeros, Fadi Shehadeh, Eleftherios Mylonakis

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

COVID-19 disproportionately affects patients with medical comorbidities such as cardiovascular disease (CVD). Patients with CVD are widely prescribed 3-hydroxy-3-methyl-glutayl-CoA (HMG-CoA) reductase inhibitors (statins), a class of lipid-lowering medications known for their pleiotropic anti-inflammatory and immunomodulatory effects. However, the relationship between statin use and COVID-19 outcomes is not fully understood. In this preliminary study, we explored the association between statin use and severe COVID-19 outcomes in hospitalized patients, including intensive care unit (ICU) admission, the need for invasive mechanical ventilation (IMV), and in-hospital death. We performed a retrospective cohort study of 249 patients hospitalized with COVID-19 from 3 March 2020 to 10 April 2020 in Rhode Island, USA. Patient demographics, past medical history, current medications, and hospital course were recorded and analyzed. A multivariate logistic regression analysis was conducted to examine associations. After adjusting for age, sex, race, cardiovascular disease, chronic pulmonary disease, diabetes, and obesity, statin use was significantly associated with decreased risk for IMV (adjusted Odds Ratio (aOR) = 0.45, 95% Confidence Interval (CI): 0.20–0.99). Our results support the continued use of statins among COVID-19 patients and could have implications for future prospective studies on the management of COVID-19.

Original languageEnglish (US)
Article number759
Pages (from-to)1-9
Number of pages9
JournalPathogens
Volume9
Issue number9
DOIs
StatePublished - Sep 2020

Keywords

  • COVID-19
  • HMG-CoA reductase inhibitors
  • Hospitalization
  • ICU
  • Invasive mechanical ventilation
  • SARS-CoV2
  • Statins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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