Staphylococcus aureus infections in pediatric patients with diabetes mellitus

Erin N. Menne, Rona Yoffe Sonabend, Edward Mason, Linda B. Lamberth, Wendy A. Hammerman, Charles G. Minard, Sheldon Kaplan, Kristina G. Hulten

    Research output: Contribution to journalArticlepeer-review

    11 Scopus citations

    Abstract

    Objectives: To describe Staphylococcus aureus infections in children with diabetes mellitus (DM). Methods: Children with DM (cases) and S. aureus infections (2/02-6/10) were identified from a surveillance database. Patient charts were reviewed, and S. aureus isolates were characterized by molecular methods. Cases were compared to age-matched controls without DM but with CA- S. aureus skin and soft tissue infections (SSTI) using conditional logistic regression. Results: Forty-seven cases were identified; 41 were matched with 123 controls. Four cases had osteomyelitis and 43 had SSTI. Mean age was 14.2 years and 63% of cases had hemoglobin (Hb) A1c levels above 10%. Cases and controls differed by gender (85% vs. 45% female, P < 0.001), BMI% (median 87% vs. 72%, P = 0.04), methicillin-resistant S. aureus (MRSA) infection (49% vs. 68%, P = 0.04), and recurrent infections (22% vs. 4%, P = 0.001). Among cases, 88% of recurrences were caused by MRSA. Conclusions: The majority of cases had poor glycemic control, more recurrences, fewer primary MRSA infections and were more likely to be female compared to a control group. Improved glycemic control may reduce the risk for infection, and decrease hospitalizations due to S. aureus infections.

    Original languageEnglish (US)
    Pages (from-to)135-141
    Number of pages7
    JournalJournal of Infection
    Volume65
    Issue number2
    DOIs
    StatePublished - Aug 2012

    Keywords

    • Diabetes
    • Glycemic index
    • Infection
    • MRSA
    • Staphylococcus aureus

    ASJC Scopus subject areas

    • Microbiology (medical)
    • Infectious Diseases

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