Staphylococcus aureus infections in pediatric patients with diabetes mellitus

Erin N. Menne, Rona Yoffe Sonabend, Edward Mason, Linda B. Lamberth, Wendy A. Hammerman, Charles G. Minard, Sheldon Kaplan, Kristina G. Hulten

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Objectives: To describe Staphylococcus aureus infections in children with diabetes mellitus (DM). Methods: Children with DM (cases) and S. aureus infections (2/02-6/10) were identified from a surveillance database. Patient charts were reviewed, and S. aureus isolates were characterized by molecular methods. Cases were compared to age-matched controls without DM but with CA- S. aureus skin and soft tissue infections (SSTI) using conditional logistic regression. Results: Forty-seven cases were identified; 41 were matched with 123 controls. Four cases had osteomyelitis and 43 had SSTI. Mean age was 14.2 years and 63% of cases had hemoglobin (Hb) A1c levels above 10%. Cases and controls differed by gender (85% vs. 45% female, P < 0.001), BMI% (median 87% vs. 72%, P = 0.04), methicillin-resistant S. aureus (MRSA) infection (49% vs. 68%, P = 0.04), and recurrent infections (22% vs. 4%, P = 0.001). Among cases, 88% of recurrences were caused by MRSA. Conclusions: The majority of cases had poor glycemic control, more recurrences, fewer primary MRSA infections and were more likely to be female compared to a control group. Improved glycemic control may reduce the risk for infection, and decrease hospitalizations due to S. aureus infections.

Original languageEnglish (US)
Pages (from-to)135-141
Number of pages7
JournalJournal of Infection
Issue number2
StatePublished - Aug 2012


  • Diabetes
  • Glycemic index
  • Infection
  • MRSA
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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