Stage-dependent analgesia of electro-acupuncture in a mouse model of cutaneous cancer pain

Qi Liang Mao-Ying, Ke Mi Cui, Qiong Liu, Zhi Qiang Dong, Wei Wang, Jun Wang, Hong Sha, Gen Cheng Wu, Yan Qing Wang

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Acupuncture is one of the most effective alternative medical treatments in pain management with the advantages of simple application, low cost and minimal side effects. However its scientific evidence and laws of action are not very clear in cancer pain relieving. The aim of this study was to examine the immediate and therapeutic anti-hyperalgesic effect of electro-acupuncture (EA) on a mouse model of cutaneous cancer pain. B16-BL6 melanoma cells were inoculated into the plantar region of unilateral hind paw and the thermal hyperalgesia was measured by using radiant heat test and hot plate test. C57BL/6 mice showed moderate and marked hyperalgesia during days 8-12 and from day 14 after the orthotopic inoculation of B16-BL6 melanoma cells into the hind paw. Single EA on day 8 after inoculation showed significant analgesic effect immediately after the treatment, the analgesic effect reached its maximum within 15-30 min and declined to its minimum at 50 min after EA treatment. Single EA treatment on day 20 showed no significant analgesic effect; Repeated EA treatments (started from day 8, once every other day) showed therapeutic analgesic effect, while it showed no therapeutic effect when started from day 16, a relatively late stage of this cancer pain model. The results demonstrated that EA had anti-hyperalgesic effect on early stage of cutaneous cancer pain but not on late stage. These results indicated a tight correlation of EA anti-hyperalgesic effects with the time window of cancer pain.

Original languageEnglish (US)
Pages (from-to)689
Number of pages1
JournalEuropean Journal of Pain
Issue number8
StatePublished - Nov 2006


  • Analgesia
  • Cutaneous cancer pain
  • Electro-acupuncture
  • Melanoma
  • Mouse

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Neurology
  • Neuropsychology and Physiological Psychology


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