Stage-Based Management of Type 2 Diabetes Mellitus with Heart Failure

Patricia Mejia Osuna, Spandana J. Brown, Laila S. Tabatabai, Dale J. Hamilton

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Type 2 diabetes negatively impacts heart failure outcomes. Insulin resistance, central adiposity, dyslipidemia, and altered cellular substrate metabolism each have a mechanistic role. Management strategies focused solely on glycemic control have had limited success. However, three new classes of drugs, each with several options, offer the promise of improved diabetes management in heart failure. Unlike earlier classes, these medications have had favorable cardiovascular outcomes. In this review, we present a therapeutic guide for metabolic treatment based on the stages of heart failure.

Original languageEnglish (US)
Pages (from-to)257-265
Number of pages9
JournalMethodist DeBakey cardiovascular journal
Issue number4
StatePublished - Oct 1 2018


  • DPP-4 inhibitors
  • GLP-1 agonists
  • SGLT2 inhibitors
  • heart failure
  • therapeutic options
  • type 2 diabetes

ASJC Scopus subject areas

  • Medicine(all)


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