Stabilization of gold nanoparticles by thiol functionalized poly(ε-Caprolactone) for the labeling of PCL biocarrier

Santosh Aryal, Remant Bahadur Remant, Narayan Bhattarai, Byoung Min Lee, Hak Yong Kim

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Polymer terminated by 2-(2,4-dinitrophenylsulfanyl) ethanol was synthesized by ring opening bulk polymerization of ε-Caprolactone initiated by the reaction product of aluminum isopropoxide and 2-(2,4-dinitrophenylsulfenyl) ethanol. The corresponding thiolyated poly(ε-Caprolactone) (PCL) was obtained after removal of protecting group under slightly basic condition. Both of PCL end capped by protected thiol and thiolyated PCL (PCLS-H) were characterized by 1H NMR and the molecular weights were determined by gel permeation chromatography (GPC). Decrease in polydispersity after deprotection was observed. The PCLS-H can be grafted to the gold nanoparticles either by direct incorporation or ligand exchange with the existing undecanethiol on the gold nanoparticles. The resulting nanoparticles were characterized by Raman spectroscopy and transmission electron microscope (TEM). Mixed ligands stabilized gold nanoparticles were further used for the labeling of PCL biocarrier by nanoprecipitation. The sizes of these nanoparticles-labeled biocarrier were determined by TEM. This is an easy and convenient way to label biocarrier by the gold nanoparticles based contrasting agent in order to study its consequences in vivo.

Original languageEnglish (US)
Pages (from-to)463-469
Number of pages7
JournalMaterials Chemistry and Physics
Volume98
Issue number2-3
DOIs
StatePublished - Aug 1 2006

Keywords

  • Biomaterials
  • Gold nanoparticles
  • Labeling
  • Polymer

ASJC Scopus subject areas

  • Materials Chemistry

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