SRC signaling in cancer and tumor microenvironment

Ayse Caner, Elif Asik, Bulent Ozpolat

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Abstract

Pioneering experiments performed by Harold Varmus and Mike Bishop in 1976 led to one of the most influential discoveries in cancer research and identified the first cancer-causing oncogene called Src. Later experimental and clinical evidence suggested that Src kinase plays a significant role in promoting tumor growth and progression and its activity is associated with poor patient survival. Thus, several Src inhibitors were developed and approved by FDA for treatment of cancer patients. Tumor microenvironment (TME) is a highly complex and dynamic milieu where significant cross-talk occurs between cancer cells and TME components, which consist of tumor-associated macrophages, fibroblasts, and other immune and vascular cells. Growth factors and chemokines activate multiple signaling cascades in TME and induce multiple kinases and pathways, including Src, leading to tumor growth, invasion/metastasis, angiogenesis, drug resistance, and progression. Here, we will systemically evaluate recent findings regarding regulation of Src and significance of targeting Src in cancer therapy.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages57-71
Number of pages15
DOIs
StatePublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1270
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Apoptosis
  • Cancer
  • Fibroblasts
  • Invasion
  • Kinase
  • Macrophages
  • Metastasis
  • Microenvironment
  • Migration
  • Motility
  • Oncogene
  • Pericytes
  • Proliferation
  • Src
  • Targeted therapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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