TY - JOUR
T1 - Sr-substituted hydroxyapatites for osteoporotic bone replacement
AU - Landi, Elena
AU - Tampieri, Anna
AU - Celotti, Giancarlo
AU - Sprio, Simone
AU - Sandri, Monica
AU - Logroscino, Giandomenico
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2007/11
Y1 - 2007/11
N2 - Porous apatites, which during resorption can release in situ Sr ions, were prepared to associate an anti-osteoporotic action with the peculiar features of the inorganic phase constituting the bone. Sr-substituted hydroxyapatite (SrHA) powder was directly synthesized using the classical neutralization route, but including Sr ions, and characterized. The higher solubility of SrHA granules of 400-600 μm size, potentially usable as a bone filler, was assessed compared with that of analogous stoichiometric HA granules. The Sr released in synthetic body fluid became constant after 1 week. The Ca release is improved for SrHA compared with stoichiometric HA, due to the higher solubility of the first material. Porous scaffolds with micro-macro interconnected porosity, which mimic the morphology of the spongy bone, were prepared by the impregnation of cellulose sponges with suspensions of the powder and a specific sintering process. A compressive strength of 4.52 ± 1.40 MPa was obtained for SrHA scaffolds characterized with 45 vol.% of porosity. Promising biomedical applications, such as resorbable bone filler or bone substitute releasing in situ Sr ions for a prolonged time, can be hypothesized for the SrHA materials when pathologies related with Sr deficiency are present.
AB - Porous apatites, which during resorption can release in situ Sr ions, were prepared to associate an anti-osteoporotic action with the peculiar features of the inorganic phase constituting the bone. Sr-substituted hydroxyapatite (SrHA) powder was directly synthesized using the classical neutralization route, but including Sr ions, and characterized. The higher solubility of SrHA granules of 400-600 μm size, potentially usable as a bone filler, was assessed compared with that of analogous stoichiometric HA granules. The Sr released in synthetic body fluid became constant after 1 week. The Ca release is improved for SrHA compared with stoichiometric HA, due to the higher solubility of the first material. Porous scaffolds with micro-macro interconnected porosity, which mimic the morphology of the spongy bone, were prepared by the impregnation of cellulose sponges with suspensions of the powder and a specific sintering process. A compressive strength of 4.52 ± 1.40 MPa was obtained for SrHA scaffolds characterized with 45 vol.% of porosity. Promising biomedical applications, such as resorbable bone filler or bone substitute releasing in situ Sr ions for a prolonged time, can be hypothesized for the SrHA materials when pathologies related with Sr deficiency are present.
KW - Biomedical applications
KW - Mechanical properties
KW - Porous scaffold
KW - Solubility test
KW - Strontium-substituted apatite
UR - http://www.scopus.com/inward/record.url?scp=34548537714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548537714&partnerID=8YFLogxK
U2 - 10.1016/j.actbio.2007.05.006
DO - 10.1016/j.actbio.2007.05.006
M3 - Article
C2 - 17618844
AN - SCOPUS:34548537714
VL - 3
SP - 961
EP - 969
JO - Acta Biomaterialia
JF - Acta Biomaterialia
SN - 1742-7061
IS - 6
ER -