Abstract
Porous apatites, which during resorption can release in situ Sr ions, were prepared to associate an anti-osteoporotic action with the peculiar features of the inorganic phase constituting the bone. Sr-substituted hydroxyapatite (SrHA) powder was directly synthesized using the classical neutralization route, but including Sr ions, and characterized. The higher solubility of SrHA granules of 400-600 μm size, potentially usable as a bone filler, was assessed compared with that of analogous stoichiometric HA granules. The Sr released in synthetic body fluid became constant after 1 week. The Ca release is improved for SrHA compared with stoichiometric HA, due to the higher solubility of the first material. Porous scaffolds with micro-macro interconnected porosity, which mimic the morphology of the spongy bone, were prepared by the impregnation of cellulose sponges with suspensions of the powder and a specific sintering process. A compressive strength of 4.52 ± 1.40 MPa was obtained for SrHA scaffolds characterized with 45 vol.% of porosity. Promising biomedical applications, such as resorbable bone filler or bone substitute releasing in situ Sr ions for a prolonged time, can be hypothesized for the SrHA materials when pathologies related with Sr deficiency are present.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 961-969 |
| Number of pages | 9 |
| Journal | Acta Biomaterialia |
| Volume | 3 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 1 2007 |
Keywords
- Biomedical applications
- Mechanical properties
- Porous scaffold
- Solubility test
- Strontium-substituted apatite
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
- Biotechnology
- Biochemistry
- Molecular Biology