Sr-substituted hydroxyapatites for osteoporotic bone replacement

Elena Landi, Anna Tampieri, Giancarlo Celotti, Simone Sprio, Monica Sandri, Giandomenico Logroscino

Research output: Contribution to journalArticle

204 Scopus citations

Abstract

Porous apatites, which during resorption can release in situ Sr ions, were prepared to associate an anti-osteoporotic action with the peculiar features of the inorganic phase constituting the bone. Sr-substituted hydroxyapatite (SrHA) powder was directly synthesized using the classical neutralization route, but including Sr ions, and characterized. The higher solubility of SrHA granules of 400-600 μm size, potentially usable as a bone filler, was assessed compared with that of analogous stoichiometric HA granules. The Sr released in synthetic body fluid became constant after 1 week. The Ca release is improved for SrHA compared with stoichiometric HA, due to the higher solubility of the first material. Porous scaffolds with micro-macro interconnected porosity, which mimic the morphology of the spongy bone, were prepared by the impregnation of cellulose sponges with suspensions of the powder and a specific sintering process. A compressive strength of 4.52 ± 1.40 MPa was obtained for SrHA scaffolds characterized with 45 vol.% of porosity. Promising biomedical applications, such as resorbable bone filler or bone substitute releasing in situ Sr ions for a prolonged time, can be hypothesized for the SrHA materials when pathologies related with Sr deficiency are present.

Original languageEnglish (US)
Pages (from-to)961-969
Number of pages9
JournalActa Biomaterialia
Volume3
Issue number6
DOIs
StatePublished - Nov 1 2007

Keywords

  • Biomedical applications
  • Mechanical properties
  • Porous scaffold
  • Solubility test
  • Strontium-substituted apatite

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology

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