Squamous metaplasia of the canaliculi associated with 5-fluorouracil: A clinicopathologic case report

Madhu R. Agarwal; Bita Esmaeli; Michael A. Burnstine

doi:10.1016/S0161-6420(02)01290-3

Squamous metaplasia of the canaliculi associated with 5-fluorouracil: A clinicopathologic case report

Madhu R. Agarwal, Bita Esmaeli, Michael A. Burnstine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Objective: To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer. Design: Interventional case report. Methods: A full-thickness section of canaliculus was obtained during surgical repair. Main Outcome Measure: Histopathologic changes in the specimen. Results: The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen. Conclusion: Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.

Original language	English (US)
Pages (from-to)	2359-2361
Number of pages	3
Journal	Ophthalmology
Volume	109
Issue number	12
DOIs	https://doi.org/10.1016/S0161-6420(02)01290-3
State	Published - Dec 1 2002

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1016/S0161-6420(02)01290-3

Cite this

@article{2b6643dd753d4563acc19705fee28f93,

title = "Squamous metaplasia of the canaliculi associated with 5-fluorouracil: A clinicopathologic case report",

abstract = "Objective: To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer. Design: Interventional case report. Methods: A full-thickness section of canaliculus was obtained during surgical repair. Main Outcome Measure: Histopathologic changes in the specimen. Results: The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen. Conclusion: Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.",

author = "Agarwal, \{Madhu R.\} and Bita Esmaeli and Burnstine, \{Michael A.\}",

year = "2002",

month = dec,

day = "1",

doi = "10.1016/S0161-6420(02)01290-3",

language = "English (US)",

volume = "109",

pages = "2359--2361",

journal = "Ophthalmology",

issn = "0161-6420",

publisher = "Elsevier",

number = "12",

}

TY - JOUR

T1 - Squamous metaplasia of the canaliculi associated with 5-fluorouracil

T2 - A clinicopathologic case report

AU - Agarwal, Madhu R.

AU - Esmaeli, Bita

AU - Burnstine, Michael A.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - Objective: To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer. Design: Interventional case report. Methods: A full-thickness section of canaliculus was obtained during surgical repair. Main Outcome Measure: Histopathologic changes in the specimen. Results: The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen. Conclusion: Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.

AB - Objective: To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer. Design: Interventional case report. Methods: A full-thickness section of canaliculus was obtained during surgical repair. Main Outcome Measure: Histopathologic changes in the specimen. Results: The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen. Conclusion: Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.

UR - https://www.scopus.com/pages/publications/0036896428

UR - https://www.scopus.com/inward/citedby.url?scp=0036896428&partnerID=8YFLogxK

U2 - 10.1016/S0161-6420(02)01290-3

DO - 10.1016/S0161-6420(02)01290-3

M3 - Article

C2 - 12466185

AN - SCOPUS:0036896428

SN - 0161-6420

VL - 109

SP - 2359

EP - 2361

JO - Ophthalmology

JF - Ophthalmology

IS - 12

ER -

Squamous metaplasia of the canaliculi associated with 5-fluorouracil: A clinicopathologic case report

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this