Squamous Cell Carcinoma Arising in Previously Burned or Irradiated Skin

Michael J. Edwards, Rose M. Hirsch, J. Ralph Broadwater, David T. Netscher, Frederick C. Ames

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

Squamous cell carcinoma (SCC) arising in previously burned or irradiated skin was reviewed in 66 patients treated between 1944 and 1986. Healing of the initial injury was complicated in 70% of patients. Mean interval from initial injury to diagnosis of SCC was 37 years. The overwhelming majority of patients presented with a chronic intractable ulcer in previously injured skin. The regional relapse rate after surgical excision was very high, 58% of all patients. Predominant patterns of recurrence were in local skin and regional lymph nodes (93% of recurrences). Survival rates at 5, 10, and 20 years were 52%, 34%, and 23%, respectively. Five-year survival rates in previously burned and irradiated patients were not significantly different (53% and 50%, respectively). This review, one of the largest reported series, better defines SCC arising in previously burned or irradiated skin as a locally aggressive disease that is distinct from SCC arising in sunlight-damaged skin. An increased awareness of the significance of chronic ulceration in scar tissue may allow earlier diagnosis. Regional disease control and survival depend on surgical resection of all known disease and may require radical lymph node dissection or amputation.

Original languageEnglish (US)
Pages (from-to)115-117
Number of pages3
JournalArchives of Surgery
Volume124
Issue number1
DOIs
StatePublished - Jan 1989

ASJC Scopus subject areas

  • Surgery

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