Spreading Pigmented Actinic Keratosis: An Electron Microscopic Study

Scott M. Dinehart, Ramon L. Sanchez

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Spreading pigmented actinic keratosis is a rarely reported premalignant, pigmented, epidermal tumor that can be difficult to distinguish clinically from other benign and malignant pigmented lesions. In an attempt to determine the cause of clinical hyperpigmentation, seven lesions from five patients were examined by light microscopy. Three of these lesions were also examined using electron microscopy. Findings from these studies indicate that hyperpigmentation is due to enhanced melanosome formation and distribution and not to a melanocytekeratinocyte melanosome transfer block.

Original languageEnglish (US)
Pages (from-to)680-683
Number of pages4
JournalArchives of Dermatology
Issue number5
StatePublished - May 1988

ASJC Scopus subject areas

  • Dermatology


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