When the tail fractions from chromatograms of sporidesmin E(I; n = 3) were rechromatographed, a new crystalline metabolite of Pithomyces chartarum was isolated with molecular formula C18H20ClN 3O6S4. The new compound, named, sporidesmin G (I; n = 4), gave sporidesmin (I; n = 2) on irradiation or treatment with triphenylphosphine, and sporidesmin D (V) after reduction and methylation. It was shown that the model compound, 1,4-dimethyl-3,6-epidithiopiperazine-2,5- dione, gave the cyclic tetrasulphide on treatment with dihydrogen disulphide. Similarly, sporidesmin and sporidesmin E when treated with dihydrogen disulphide gave the new metabolite.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|State||Published - 1972|
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