Sporidesmins. Part XII. Isolation and structure of sporidesmin G, a naturally-occurring 3,6-epitetrathiopiperazine-2,5-dione

E. Francis, R. Rahman, S. Safe, A. Taylor

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

When the tail fractions from chromatograms of sporidesmin E(I; n = 3) were rechromatographed, a new crystalline metabolite of Pithomyces chartarum was isolated with molecular formula C18H20ClN 3O6S4. The new compound, named, sporidesmin G (I; n = 4), gave sporidesmin (I; n = 2) on irradiation or treatment with triphenylphosphine, and sporidesmin D (V) after reduction and methylation. It was shown that the model compound, 1,4-dimethyl-3,6-epidithiopiperazine-2,5- dione, gave the cyclic tetrasulphide on treatment with dihydrogen disulphide. Similarly, sporidesmin and sporidesmin E when treated with dihydrogen disulphide gave the new metabolite.

Original languageEnglish (US)
Pages (from-to)470-472
Number of pages3
JournalJournal of the Chemical Society, Perkin Transactions 1
DOIs
StatePublished - 1972

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Sporidesmins. Part XII. Isolation and structure of sporidesmin G, a naturally-occurring 3,6-epitetrathiopiperazine-2,5-dione'. Together they form a unique fingerprint.

Cite this