Spontaneous pressure-flow relationships in renal circulation of conscious dogs

S. Skarlatos, N. DiPaola, R. A. Frankel, R. W. Pomerantz, P. H. Brand, P. J. Metting, S. L. Britton

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Renal pressure-flow (P-F) relationships are usually evaluated by measuring effects of mechanically induced changes in renal arterial pressure (AP) on renal blood flow (RBF). We devised a method allowing evaluation of renal P-F relationships during normal changes in AP occurring spontaneously in a conscious animal rather than during artificially induced changes in AP. In 18 trials in 6 dogs standing at rest, we measured average AP and RBF for each cardiac cycle over periods of ~35 min (~3,100 cardiac cycles/trial). AP and RBF values for each cardiac cycle were expressed as percent change (%Δ) from the 35-min average (beat-to-beat changes). Slope and angle of each consecutive beat-to-beat P-F change were calculated and collated into one of eight zones representing the possible physiological mechanisms responsible for concurrent, spontaneous changes in RBF and AP. In a predominance of the cardiac cycles (~43%), the spontaneous AP-RBF relationship was consistent with being mediated by arterial baroreflexes (i.e., increases in AP were accompanied by proportionately greater increases in RBF during 44.4% of cardiac cycles in which AP increased, and decreases in AP were accompanied by proportionately greater decreases in RBF during 41.4% of cardiac cycles in which AP decreased). Blockade of autonomic ganglionic transmission with hexamethonium markedly attenuated this pattern. Our results indicate that renal circulation participates in moment-to-moment control of AP via a predominant baroreflex-like pattern.

Original languageEnglish (US)
Pages (from-to)H1517-H1527
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume264
Issue number5 33-5
DOIs
StatePublished - 1993

Keywords

  • autonomic nervous system
  • autoregulation
  • baroreflex
  • myogenic response
  • neural influence
  • regulation
  • renal blood flow
  • state dependency

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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