Splendore-Hoeppli phenomenon in bronchocentric granulomatosis

The formation of eosinophilic radiate structures around fungi, helminth ova, and certain bacteria is most commonly called the Splendor-Hoeppli phenomenon. It has been sporadically described since the early twentieth century, mainly in the veterinary fields. We report a striking example of this rare phenomenon in a human lung in which granulomatous fungal infection was noted. The bronchocentric or bronchiolocentric location of the granulomas in our case indicated bronchocentric granulomatosis, in which the Splendore-Hoeppli phenomenon has not previously been described.