Spinocerebellar ataxia type 10: Frequency of epilepsy in a large sample of Brazilian patients

Hélio A G Teive; Renato P. Munhoz; Salmo Raskin; Walter O. Arruda; Luciano De Paola; Lineu C. Werneck; Tetsuo Ashizawa

doi:10.1002/mds.23324

Spinocerebellar ataxia type 10: Frequency of epilepsy in a large sample of Brazilian patients

Hélio A G Teive, Renato P. Munhoz, Salmo Raskin, Walter O. Arruda, Luciano De Paola, Lineu C. Werneck, Tetsuo Ashizawa

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder caused by an ATTCT repeat intronic expansion in the SCA10 gene. SCA 10 has been reported in Mexican, Brazilian, Argentinean and Venezuelan families. Its phenotype is overall characterized by cerebellar ataxia and epilepsy. Interestingly, Brazilian patients reported so far showed pure cerebellar ataxia, without epilepsy. Here, authors provide a systematic analysis of the presence, frequency and electroencephalographic presentation of epilepsy among 80 SCA10 patients from 10 Brazilian families. Overall, the frequency of epilepsy was considered rare, been found in 3.75 % of the cases while this finding in populations from other geographic areas reaches 60% of SCA10 cases.

Original language	English (US)
Pages (from-to)	2875-2878
Number of pages	4
Journal	Movement Disorders
Volume	25
Issue number	16
DOIs	https://doi.org/10.1002/mds.23324
State	Published - Dec 15 2010

Keywords

Autosomal dominant cerebellar ataxia
Epilepsy
SCA
Spinocerebellar ataxia type 10

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.23324

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title = "Spinocerebellar ataxia type 10: Frequency of epilepsy in a large sample of Brazilian patients",

abstract = "Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder caused by an ATTCT repeat intronic expansion in the SCA10 gene. SCA 10 has been reported in Mexican, Brazilian, Argentinean and Venezuelan families. Its phenotype is overall characterized by cerebellar ataxia and epilepsy. Interestingly, Brazilian patients reported so far showed pure cerebellar ataxia, without epilepsy. Here, authors provide a systematic analysis of the presence, frequency and electroencephalographic presentation of epilepsy among 80 SCA10 patients from 10 Brazilian families. Overall, the frequency of epilepsy was considered rare, been found in 3.75 % of the cases while this finding in populations from other geographic areas reaches 60% of SCA10 cases.",

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AU - Teive, Hélio A G

AU - Munhoz, Renato P.

AU - Raskin, Salmo

AU - Arruda, Walter O.

AU - De Paola, Luciano

AU - Werneck, Lineu C.

AU - Ashizawa, Tetsuo

PY - 2010/12/15

Y1 - 2010/12/15

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AB - Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder caused by an ATTCT repeat intronic expansion in the SCA10 gene. SCA 10 has been reported in Mexican, Brazilian, Argentinean and Venezuelan families. Its phenotype is overall characterized by cerebellar ataxia and epilepsy. Interestingly, Brazilian patients reported so far showed pure cerebellar ataxia, without epilepsy. Here, authors provide a systematic analysis of the presence, frequency and electroencephalographic presentation of epilepsy among 80 SCA10 patients from 10 Brazilian families. Overall, the frequency of epilepsy was considered rare, been found in 3.75 % of the cases while this finding in populations from other geographic areas reaches 60% of SCA10 cases.

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Spinocerebellar ataxia type 10: Frequency of epilepsy in a large sample of Brazilian patients

Abstract

Keywords

ASJC Scopus subject areas

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