Spinocerebellar ataxia type 10 - A review

Hélio A G Teive, Renato P. Munhoz, Walter O. Arruda, Salmo Raskin, Lineu César Werneck, Tetsuo Ashizawa

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant inherited ataxia caused by an expanded ATTCT pentanucleotide repeat in intron 9 of the ATXN10 gene, on chromosome 22q13.3. SCA10 represents a rare form of SCA, until now only described in Latin America, particularly in Mexico, Brazil, Argentina and Venezuela. In Mexico and Brazil SCA10 represents the second most common type of autosomal dominant cerebellar ataxia. The phenotype described in Mexico, is characterized by the association of cerebellar ataxia with epilepsy, while in Brazil the SCA10 phenotype is that of a pure cerebellar ataxia. As yet unidentified genotypic variables may account for this phenotypic difference.

Original languageEnglish (US)
Pages (from-to)655-661
Number of pages7
JournalParkinsonism and Related Disorders
Volume17
Issue number9
DOIs
StatePublished - Nov 2011

Keywords

  • Cerebellar ataxia
  • Epilepsy
  • Pure cerebellar ataxia
  • SCA10
  • Spinocerebellar ataxia

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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