Abstract
(Figure Presented) Electrical traps with Raman hot spots: On-wire-lithography (OWL) nanotraps electrically localize DNA in a nanometerscale gap (see picture, red oligonucleotides with Raman dyes), which allows for the identification of the localized material by surface-enhanced Raman spectroscopy. With microfluidic delivery, sample volumes as small as 1 mL with target concentrations as low as 230 fm can be studied without secondary amplification.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1938-1941 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 47 |
| Issue number | 10 |
| DOIs | |
| State | Published - Feb 22 2008 |
Keywords
- DNA
- Electric field
- Lithography
- Nanotechnology
- Surface-enhanced Raman spectroscopy
ASJC Scopus subject areas
- General Chemistry
- Catalysis
- General Medicine