Abstract
(Figure Presented) Electrical traps with Raman hot spots: On-wire-lithography (OWL) nanotraps electrically localize DNA in a nanometerscale gap (see picture, red oligonucleotides with Raman dyes), which allows for the identification of the localized material by surface-enhanced Raman spectroscopy. With microfluidic delivery, sample volumes as small as 1 mL with target concentrations as low as 230 fm can be studied without secondary amplification.
Original language | English (US) |
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Pages (from-to) | 1938-1941 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 47 |
Issue number | 10 |
DOIs | |
State | Published - Feb 22 2008 |
Keywords
- DNA
- Electric field
- Lithography
- Nanotechnology
- Surface-enhanced Raman spectroscopy
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
- Medicine(all)