TY - JOUR
T1 - Specificity of neonatal, androgen-induced imprinting of hepatic steroid metabolism in rats
AU - Gustafsson, Jan Åke
AU - Stenberg, Å K.E.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1976
Y1 - 1976
N2 - The specificity of the neonatal, androgen induced, irreversible programming of hepatic steroid metabolism in the rat was investigated. 5α Dihydrotestosterone propionate and estradiol benzoate were as efficient as testosterone proprionate in inducing a male type of liver metabolism in the adult animal, whereas epitestosterone proprionate, etiocholanolone proprionate, and o,p DDT were practically inactive in this respect. These findings indicate that different mechanisms are involved in neonatal imprinting of hepatic steroid metabolism and in the well known neonatal androgenic and estrogenic induction of persistent estrus and acyclic gonadotropin secretion.
AB - The specificity of the neonatal, androgen induced, irreversible programming of hepatic steroid metabolism in the rat was investigated. 5α Dihydrotestosterone propionate and estradiol benzoate were as efficient as testosterone proprionate in inducing a male type of liver metabolism in the adult animal, whereas epitestosterone proprionate, etiocholanolone proprionate, and o,p DDT were practically inactive in this respect. These findings indicate that different mechanisms are involved in neonatal imprinting of hepatic steroid metabolism and in the well known neonatal androgenic and estrogenic induction of persistent estrus and acyclic gonadotropin secretion.
UR - http://www.scopus.com/inward/record.url?scp=0017282180&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017282180&partnerID=8YFLogxK
U2 - 10.1126/science.1246611
DO - 10.1126/science.1246611
M3 - Article
C2 - 1246611
AN - SCOPUS:0017282180
VL - 191
SP - 203
EP - 204
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
SN - 0036-8075
IS - 4223
ER -