Specific detection and effective inhibition of a single bacterial species in situ using peptide mineralized Au cluster probes

Xiangchun Zhang, Li Liu, Ru Liu, Jing Wang, Xuhu Hu, Qing Yuan, Juanjuan Guo, Gengmei Xing, Yuliang Zhao, Xueyun Gao

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Increasingly serious microbial infections call for the development of new simpler methods for the precise diagnosis and specific inhibition of such pathogens. In this work, a peptide mineralized Au cluster probe was applied as a new simplified strategy to both recognize and inhibit a single bacteria species of Staphylococcus aureus (S. aureus) simultaneously. The probes are composed of peptides and Au clusters. Moreover, the peptides specifically target S. aureus cells and the Au clusters provide fluorescent imaging and have an antibacterial effect. These new probes enable the simultaneous specific detection and effective destruction S. aureus cells in situ.

Original languageEnglish (US)
Pages (from-to)627-634
Number of pages8
JournalScience China Chemistry
Volume61
Issue number5
DOIs
StatePublished - May 1 2018

Keywords

  • Au cluster probes
  • S. aureus
  • effective inhibition
  • single bacteria species
  • specific detection

ASJC Scopus subject areas

  • Chemistry(all)

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