Special delivery: Targeted therapy with small RNAs

D. Peer, J. Lieberman

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations


Harnessing RNA interference using small RNA-based drugs has great potential to develop drugs designed to knock down expression of any disease-causing gene, thereby greatly expanding the universe of possible drug targets. However, delivering small RNAs into specific tissues and cells is still a hurdle. Here, we review recent progress in overcoming systemic, local and cellular barriers to RNA drug delivery, focusing on strategies for targeted uptake.

Original languageEnglish (US)
Pages (from-to)1127-1133
Number of pages7
JournalGene Therapy
Issue number12
StatePublished - Dec 2011


  • aptamer
  • drug
  • liposome
  • nanoparticle
  • siRNA

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics


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