393 Scopus citations

Abstract

Specificity protein 1 (Sp1) and other Sp and Krüppel-like factor (KLF) proteins are members of a family of transcription factors which bind GC/GT-rich promoter elements through three C2H2-type zinc fingers that are present at their C-terminal domains. Sp1-Sp4 proteins regulate expression of multiple genes in normal tissues and tumours. There is growing evidence that some Sp proteins play a critical role in the growth and metastasis of many tumour types by regulating expression of cell cycle genes and vascular endothelial growth factor. Sp/KLF proteins are also potential targets for cancer chemotherapy.

Original languageEnglish (US)
Pages (from-to)2438-2448
Number of pages11
JournalEuropean Journal of Cancer
Volume41
Issue number16
DOIs
StatePublished - Nov 2005

Keywords

  • Cancer
  • Sp1
  • Sp2
  • Sp3
  • Sp4
  • Transcription factors
  • VEGF

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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