Abstract
Specificity protein 1 (Sp1) and other Sp and Krüppel-like factor (KLF) proteins are members of a family of transcription factors which bind GC/GT-rich promoter elements through three C2H2-type zinc fingers that are present at their C-terminal domains. Sp1-Sp4 proteins regulate expression of multiple genes in normal tissues and tumours. There is growing evidence that some Sp proteins play a critical role in the growth and metastasis of many tumour types by regulating expression of cell cycle genes and vascular endothelial growth factor. Sp/KLF proteins are also potential targets for cancer chemotherapy.
Original language | English (US) |
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Pages (from-to) | 2438-2448 |
Number of pages | 11 |
Journal | European Journal of Cancer |
Volume | 41 |
Issue number | 16 |
DOIs | |
State | Published - Nov 2005 |
Keywords
- Cancer
- Sp1
- Sp2
- Sp3
- Sp4
- Transcription factors
- VEGF
ASJC Scopus subject areas
- Oncology
- Cancer Research